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edterry
11-13-2008, 06:09 PM
I just had the VAP test performed and I'm really puzzled about my LDL Pattern. My numbers were:
LDL 53
HDL 49
VLDL 12
Triglycerides 56
Lp(a) 5.0 (range 0 - 10)
IDL 2

LDL1 Pattern A 2.9 (large fluffy type)
LDL2 Pattern A 2.1 (large fluffy type)
LDL3 Pattern B 26.7 (small dense LDL)
LDL4 Pattern B 14.7 (small dense LDL)

Everything I've read says that to increase LDL size, take Niacin, lose weight, and eat right (low carb). Problem is I've been taking Niacin and fish oil for 5 years; lost 30 lbs in the last year and a half (BMI now 24.9), exercise religiously (cardio and strength training) and eating low carb. I have a very strong family history of heart disease and stroke so there's probably a strong genetic disposition toward that. My only consolation is that with my low LDL, there's probably not a large number of small, dense LDL particles running around. Assuming I want to improve my LDL pattern, are there any other approaches I can add to improve my LDL particle size?

lczeledoc
11-14-2008, 01:55 PM
Saturated fat intake has been shown to correlate with LDL particle size.

edterry
11-15-2008, 07:04 AM
I came across this abstract from a Japanese journal article.

Effects of eicosapentaenoic acid on plasma lipoprotein subfractions and activities of lecithin:cholesterol acyltransferase and lipid transfer protein.
Homma Y, Ohshima K, Yamaguchi H, Nakamura H, Araki G, Goto Y:. Department of Internal Medicine, Tokai University School of Medicine, Isehara, Japan.

The effects of 12 weeks eicosapentaenoic acid (EPA) administration (2.7 g/day) on plasma lipoprotein subfraction levels. Plasma VLDL-C, VLDL-TG, VLDL-PL, VLDL-apo B, VLDL-apo C-II and VLDL-apo C-III levels were decreased by 32.8%, 31.2%, 31.5%, 32.5%,34.7% and 34.1%, respectively.
EPA did not change plasma IDL-TC, IDL-TG, IDL-PL and IDL-apo B levels. Plasma large, light LDL (LDL1)-TC, LDL1-PL and LDL1-apo B levels were decreased by EPA by 18.7%, 19.1% and 23.3% while LDL1-TG level was not changed. Plasma small, heavy LDL (LDL2)-TC level was increased by 25.7% while LDL2-TG, LDL2-PL and LDL2-apo B levels were not altered.
Plasma HDL2-TC, HDL2-TG, HDL2-PL and HDL2-apo A-I levels stayed unchanged by EPA treatment. EPA did not affect plasma HDL3-TC, HDL3-PL and HDL3-apo A-I levels but decreased HDL3-TG level significantly.
We conclude that EPA reduces plasma large, light LDL levels as well as plasma VLDL amounts and stimulates LTP activities.

I've been taking a large dose of fish oil. I'm not cutting my dose in half and rechecking LDL cholesterol pattern in 3 months.