Triglycerides and LDL

[MeDieViL]

http://forum.lowcarber.org/showthread.php?t=306841

i've just read this post at lowcarber, and basicly i'm looking for the studies confirming this
There have been enough studies done now showing that triglycerides are a surrogate marker for LDL particle size--high triglycerides indicate small dense LDL; low triglycerides mean large fluffy, type A, LDL--that I don't bother with the expensive test any longer.

Thx:D

[Gaelen]

Welcome in, MeDieVil.
We don't really answer here for posts or information that you found elsewhere--this community encourages everyone to back up posts made here with references whenever possible, but when it comes to proving or disproving statements seen elsewhere or made by others, well...that responsibility does lie with the original poster. ;) OTOH, if it's a subject that interests you, there are many people here who can point you in the right direction for doing a bit of your own research. It's always easier, IMO, to understand someone else's point of view after I actually doing a little homework of my own--no matter how on or off target their POV may be. YMMV.

Have you tried searching for the 'studies' alluded to by using medical search engines?

[banshee]

I knew I had read this somewhere, and I thought it was Dr. Mike's blog. Sure enough, in the comments section of the "Saturated fats study sucks (http://www.proteinpower.com/drmike/archives/2006/08/saturated_fat_s.html)" blog post, Dr. Mike responds to a comment, and in the response, says exactly what is quoted above (The lowcarb-forum posting is actually a copy of this comment/response.) In another response to a different comment in the same post, Dr. Mike also says (emphasis mine):

In virtually all studies I've seen and in all the patients MD and I have actually checked first hand, increasing the fat and decreasing the carbs in the diet shift the LDL from the small, dense to the larger, fluffier variety.

Unfortunately, he doesn't list the studies, but he's usually pretty good at responding to comments in his blog, so MeDieViL, maybe you could post a comment in the above blog post and ask him?

(Out of curiosity I did a Google search for "triglyceride levels and LDL particle size" and another for "triglyceride and LDL particle size" and came up with a bunch of results that looked relevant. I read the first few paragraphs of several, and pretty much all of them agreed with what Dr. Mike says. Here's the link to one of them (http://atvb.ahajournals.org/cgi/content/abstract/12/11/1284). Here's another one (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=8782637). And another (http://www.medscape.com/viewarticle/420330). A google search like that should be a good place to start, and the articles I linked should give you some researchers names to do further refinements...)

[ceberezin]

What I have read is that LDL starts out as a VLDL, or very low density lipoprotein, the soluble envelope for transporting otherwise insoluble lipids through the blood. The VLDL has two major components, triglycerides and cholesterol. The first thing the VLDL does is deposit the triglycerides into adipocytes for fat storage. What's left over is now called LDL and consists mainly of cholesterol. If you've been eating high carbohydrate, your liver is busily converting all that glucose into fat through de novo lipogenesis which is the source of all those triglycerides. So the VLDL fills up mostly with triglycerides and a little cholesterol. After the VLDL deposits its triglycerides, the resulting particle of LDL is small and dense. If you've been eating low carbohydrate, then there is less triglyceride to fill up the VLDL and the proportion of cholesterol in the VLDL is higher. So the resulting LDL particle is larger and fluffier. Now if only I can remember where I read this.

[MeDieViL]

What I have read is that LDL starts out as a VLDL, or very low density lipoprotein, the soluble envelope for transporting otherwise insoluble lipids through the blood. The VLDL has two major components, triglycerides and cholesterol. The first thing the VLDL does is deposit the triglycerides into adipocytes for fat storage. What's left over is now called LDL and consists mainly of cholesterol. If you've been eating high carbohydrate, your liver is busily converting all that glucose into fat through de novo lipogenesis which is the source of all those triglycerides. So the VLDL fills up mostly with triglycerides and a little cholesterol. After the VLDL deposits its triglycerides, the resulting particle of LDL is small and dense. If you've been eating low carbohydrate, then there is less triglyceride to fill up the VLDL and the proportion of cholesterol in the VLDL is higher. So the resulting LDL particle is larger and fluffier. Now if only I can remember where I read this.i don't agree with the fact it deposits triglycerides in the adipose tissue, i dont think you can store fat, but i'l look into it thx

@banshee thx

@Gaelen
all the information comes from protein power lol:D