The last post I wrote was on statin drugs and the couple before that were on the many benefits of vitamin D, one of which is the prevention of heart disease. According to a number of papers, statin drugs seem to increase levels of vitamin D in those who take them, which makes me wonder if any benefits that statins provide don’t come from this increase in vitamin D levels. If so, it would be a whole lot cheaper and a whole lot safer to simply take vitamin D3 supplements.

This issue reminds me of a talk on the mechanism of action of statins that I sat through at a medical meeting in Napa, California about 10 years ago. At that time researchers knew that along with their cholesterol-lowering capabilities statins also acted as anti-inflammatory agents. Statins increase the production of nitric oxide, an extremely short acting substance that has relaxing and anti-inflammatory effects on the lining of the arteries. The researcher giving the talk was from Harvard, and he had done a study in which he compared the nitric oxide releasing ability of l-arginine (an amino acid) and a statin drug. He found that the way that statins increased the production of nitric oxide mimicked the way l-arginine did the same thing. He proudly announced that his research showed for the first time how statins really worked to exert their anti-inflammatory effects. I wondered at the time why he didn’t just recommend that patients be given l-arginine – a natural substance with virtually no side effects – instead of statins? I would have asked the question, but this was a mainstream medical meeting, and I figured if I asked that question I might be stoned.

Thanks to this and subsequent research, we know that the anti-inflammatory benefits provided by statins can be had cheaper and more safely by taking l-arginine, available at health stores everywhere. ( Incidentally, know what the best natural source of l-arginine is? Wild game. Just another piece of evidence in favor of a Paleolithic diet.) And now we know that statins increase production of vitamin D, another heart-healthy substance.

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Just got in from a whirlwind trip to New York, which ended up what with family and business obligations being the busiest trip there I’ve ever experienced. MD and I have just enough time to go through the mail, do laundry and head back to the airport to fly to Dallas for Christmas. Once back, we’ll have some time of our own.

I have to apologize yet again for not answering the many comments that have stacked up. I simply haven’t had time. But I will get to them, I promise.

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MD and I have been subsumed by the whirlwind we’ve been in since our arrival in New York a couple of days ago. It seems as if we’ve trekked from first one meeting to the next without a break in between. I haven’t had time to post, and I’m woefully behind on answering and posting comments that have come in (about 80 at last count). If you’ve sent a comment and wondered why it has apparently vanished, now you know why. Don’t despair. I think I’ll have some down time this weekend so that I can catch up.

It’s been a while since I’ve been to New York in December, and I hadn’t remembered how short the days are and how dark and overcast as compared to Santa Barbara and Lake Tahoe, both places of almost constant sunshine. While contemplating this lack of sun I came across an article (actually a letter in response to an earlier article) in the journal Epidemiology and Infection that I found interesting and wanted to pass along. (Unfortunately there is no abstract for this article, so I’m not providing a link.)

Dr. John Aloia and his group at the Bone Mineral Research Center at Winthrop University Hospital in New York reported on a three-year study they had done on 208 African American postmenopausal women (a group at great risk of vitamin D deficiency) who were supplemented with either vitamin D or a placebo. For the first two years the active group received 800 IU daily, which was increased to 2,000 IU daily in the last year of the study. In the three years of the study 34 patients reported cold and flu symptoms, eight in the supplemented group and 26 in the placebo group (p<0.002). This showed that participants who got a placebo had a 300-percent greater risk of having a cold or flu, and that vitamin D supplementation provided a highly significant protective effect.

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Merck has developed a “new” folate supplement that is much improved over the folic acid now used for both supplements and food fortification. I say “new” because this supplement, though brought to us through the magic of chemistry, is methylfolate, the same chemical structure as the compound that is found in foods. Folate in this form has been available in the US for several years now, but due to its the expense, a different form of folate is used in supplements and for food fortification.

A recent British Medical Journal article describes the type of folic acid commonly used:

The form of folate in supplements and in fortified foods is pteroylmonoglutamate (PGA), a form that does not occur in nature. It is both cheap and stable unlike most native forms of the vitamin. The body metabolises PGA into methylfolate, the normal form of the vitamin transported in plasma. However, research shows that this absorption and biotransformation process is saturated at doses in the region of 400 µg PGA or less. Thus at doses at or just below 400 µg PGA all this synthetic form of folate is converted into biologically active methylfolate during absorption. At higher doses synthetic PGA is also transported into the blood in a manner that is directly proportional to dose. This raises the possibility of a lifetime’s exposure to unmetabolised PGA where mandatory fortification is undertaken. Although such exposure may present no health risk at all, we cannot know this for certain.

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