Archive for the 'Cardiovascular disease' Category

Statinators spill the beans

Oftentimes people become so fixed in their thinking – and in their belief that everyone else thinks the same way – that they unwittingly raise the curtain and expose the wizard of their flawed thinking, showing it for what it really is.  Statinators have done just that in an article in the current issue of the Journal of the American College of Cardiology (JACC).

The study, Effects of High-Dose Modified-Release Nicotinic Acid on Atherosclerosis and Vascular Function, compares the increase in carotid artery plaque over a 12-month period in subjects taking niacin versus those taking a placebo.  It turns out that those subjects taking the niacin experienced a shrinkage of their plaque whereas plaque grew larger on those taking the placebo. The revealing hitch in this study is that both groups were on statins, which means the group on statins alone was the placebo group.  Therefore the data from this study shows that statins alone do not reverse the growth of plaque (at least not plaque in the carotid arteries) despite lowering LDL levels.  Taking the logic a little further, the data from this study gives weight to the idea that a lowered LDL doesn’t reduce plaque growth.

There is a lot we can glean from this study and the from the authors’ commentary on it.

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Do statinators dream of engineered mice?

genetically engineered mouse

A paper appeared recently in the prestigious Proceedings of the National Academy of Sciences (PNAS) that seems to have a whole lot of people on edge.  If you read the press accounts of this study, you might think anyone stupid enough to follow a low-carb diet would be doomed to certain death from heart attack.  But is that the case?  Or is it simply another instance of the media either failing to understand how science works or, worse, misreporting to get a better story?

I suspect the latter, but before we get into it, I need to go over a few blog housekeeping issues.

As I’m sure everyone has noticed, the look of this blog has changed – as has the look of the entire website.  Our designer and tech guys have been struggling to get everything working right, but, finally, my incessant whining got to them, and they went ahead and put the thing up in its not-completed state.  Please bear with us – it will ultimately work as it’s supposed to.  If you are having a problem, send me a description in the comments section.  Make sure you tell me what kind of computer you’re using (Mac (Intel or pre-Intel)  or PC) and which browser (Firefox, Internet Explorer, Safari, etc.) so that the gurus will know what to do to fix it.

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Hard at work in Seattle

Mt St Helens blog

I haven’t posted in a week because MD and I have been hard at work in Seattle and at Orcas Island, the largest of the San Juan Islands located in northwestern Washington.

We’re working on our project that we’ve been keeping under wrap.  No, it’s not the new book, and, no, it’s not Metabosol.  It is something pretty cool and even revolutionary in its own way.  Barring further bumps in the road (there have been a few), we should be able to reveal all on September 1. The reason for the secrecy is that this project is most press worthy, but, for reasons that will be obvious when we reveal what we’ve been working on, we don’t want the press to report it prematurely.

We flew into Seattle Sunday afternoon after buzzing across the top of Mount St. Helens and looking into the crater left when the top 1300 feet of the mountain blew off on May 18, 1980.  After landing, we got picked up by our partner and taken to his boat for an afternoon on Lake Union.  A huge annual celebration was taking place, so we spent the afternoon on a lake made choppy by a thousand other boats while the Blue Angels zipped through the sky overhead.  Seattle has been experiencing brutally hot temperatures, which we got blasted by on Sunday afternoon.

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Rebuttal to the PCRM

eades-whisky

In my ongoing quest to become a little more technically adept, I started using Google Alerts for a number of things I’m interested in, including my own name.  (Believe me, there are a lot of people out there in the world with the last name Eades, including the Fire Chief of London.)  For those of you who don’t know, you can go to the Google main page and navigate around until you come to ‘Alerts.’  You can then sign up for these ‘Alerts’ to be delivered to you via email.  It’s a free service provided by Google, and it uses the Google system to crawl through cyberspace and find anything (blogs, articles, news reports, etc.) that has whatever word, words or phrases you submitted included and emails the link back to you.  I put a bunch of stuff in and get emails from Google throughout the day.  Most of it is stuff that is totally unrelated to anything I give a flip about, but every now and then it turns up something of interest.  Having my name listed has cost me money because one of the first things I that came back to me was an article about Eades Whisky, which I had no idea existed and which I had to try.  It is expensive, about $75 per bottle, but I ordered some.  It’s very good.  But it hasn’t replaced Jameson, however, by a long shot.

Yesterday I got back a hit about something that I had totally forgotten about:  our rebuttal to the idiotic ’study’ presented by the PCRM (Physician’s Committee for Responsible Medicine – a name straight out of Orwell if there ever was one) a few years ago.  This group, composed mainly of militant vegetarians, came up with an insipid ’study’ during the height of the low-carb frenzy back in 2003.  Neal Barnard, the head of the outfit, appeared on most of the morning talk shows telling how dangerous his study had found low-carb diets to be.  A couple of the national networks called MD and me asking us if we would provide a rebuttal.  We happened to be in Santa Barbara at the time, and we said sure.  Two different networks sent camera crews to interview us late in the afternoon.

As I’ve probably mentioned numerous times, we have an absolute knack for getting pre-empted whenever we get TV time.  This day was no exception.  The news teams were on their way to the little condo we had at the time to set up and shoot our rebuttal when the news came through that Michael Jackson was going to be flying in to the Santa Barbara airport to turn himself in on the child molestation charge that he later beat in court.  Of course, all the news vans and camera crews that were heading for our place were diverted to the Santa Barbara airport, and MD and I never got to rebut the PCRM idiocy on air.

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