Health & Nutrition by Michael R. Eades, M.D.

Gary and me on our front porch. Photo by MD Eades 8/13/2008

A couple of days ago Gary Taubes, who was visiting family in Los Angeles, drove up to Santa Barbara, and he, MD and I got together for a long lunch. We talked about all the things we always discuss, most of which have nothing to do with nutrition or nutritional science. But, as always when we get together, talk did turn to science and the sorry state of nutritional science in the world today.

We discussed a Stanford study that was recently published in the Archives of Internal Medicine demonstrating that those who are runners live longer and have less disability. The paper proves absolutely nothing, yet an enormous number of people, many of whom should know better, profess that this study is the smoking gun that ties exercise to longevity and health.

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Aubrey de Grey (here, here and here) is an iconoclastic anti-aging researcher living in Cambridge, UK who approaches the science of anti-aging medicine from an engineering perspective (requires free registration). He lectures extensively and constantly pushes the boundaries of anti-aging research. He isn’t trained in biology or medicine, but as an engineer. His extensive knowledge of medicine and the biological sciences is pretty much self taught. He doesn’t subscribe to any particular medical or scientific ideology, i.e., alternative medicine verses mainstream medicine, or any specific dietary practices other than the idea that caloric restriction has been shown in animal studies to prolong life. But Dr. de Grey isn’t interested in the mere 20-30 percent increase in lifespan brought about by caloric restriction; he’s more interested in increasing lifespan 100 to 200 years or more. Which he believes can be done if we look at forestalling aging from an engineering point of view.

He has written (co-written, actually) a book titled, appropriately enough, Ending Aging describing his theories of aging and discussing the problems that must be overcome to undo the forces of our own biochemistry and physiology that grind us down over time. I read the book when it first came out and found it fascinating. I wouldn’t think it’s a particularly an easy read for one not scientifically inclined. If you thought Gary Taubes’ book was difficult, I wouldn’t recommend this one. If you do get it and are prepared to spend some time really digging in, you will come away rewarded, if not in understanding (which you will certainly get) at least in the knowledge that there are many extremely clever people working to keep us living longer. If you just want to read a little of the book, I recommend Chapter 5, Meltdown of the Cellular Power Plants, which is a virtuoso piece of scientific reasoning. Dr. de Grey published his theory of mitochondrial survival of the slowest, the subject of this chapter, a few years back, and I thought it a brilliant piece of scientific detective work.

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While reading a scientific paper on the benefits of a carnivorous diet I noticed a paper in the list of references at the end that I had never seen cited. I tracked the paper down, read it, and learned that vegetarians have significantly higher rates of advanced glycation end products (AGE) than do omnivores.

Before we get into the study, let’s take a moment and discuss AGEs so we’ll all be on the same page. When proteins are incubated with sugars, over time the sugar attaches irreversibly with the protein in a process called glycation. (There are many names for the reaction: the Maillard reaction, Schiff’s base formation, the Amadori reaction, etc. with minor differences between these different processes, but debating the differences is pointless for our purposes.) If the protein performs a specific function in the body due to its unique structural conformation, and it finds itself with a sugar attached to it that it can’t get rid of, then this protein suddenly doesn’t function so well and becomes a junk protein that the body has to dispose of.

Since most of the structures in our bodies are made of protein, and since all of these proteins are bathed in blood that contains glucose, the normal course of events is for a portion of these proteins to undergo glycation. And the longer the proteins are in contact with the sugar, the more glycated proteins will be formed. All this goes on continuously in our bodies so as we age we accumulate more and more of these substances, thus the clever name AGEs.

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An annoying comment I hear all the time whenever I talk about how Ancel Keys set the country on the disastrous nutritional course it has been on for the last 40 years runs something like this: ‘I dunno. Key’s must have been doing something right because he lived to be 100.’

First, the fact that Key’s himself lived to be 100 doesn’t mean squat. Everyone has a relative somewhere that defied the odds. I would bet that just about anyone can name someone who smoked, drank and was obese who lived to a ripe old age. Winston Churchill, for one, comes to mind. Smoked, loved his booze, was obviously obese, and lived to be 90. It’s not the individuals that matter in terms of health and longevity, but populations as a whole. And since the US (and now the world, it seems) has been following the wisdom of Ancel Keys, look what has happened. Obesity and diabetes are at epidemic levels. So, while Ancel himself lived a long life, I’m not so sure a lot of his victims will.

But, since people obnoxiously continue to point out that Keys made it to triple digits by allegedly following his own recommendations, let’s look at another individual (which, again, mean nothing in scientific terms) for comparison’s sake.

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