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	<title>Comments on: Truth versus hype in the Jupiter study</title>
	<atom:link href="http://www.proteinpower.com/drmike/cardiovascular-disease/1853/feed/" rel="self" type="application/rss+xml" />
	<link>http://www.proteinpower.com/drmike/cardiovascular-disease/1853/</link>
	<description>A critical look at nutritional science and anything else that strikes my fancy.</description>
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		<title>By: Julie Lange</title>
		<link>http://www.proteinpower.com/drmike/cardiovascular-disease/1853/comment-page-2/#comment-226656</link>
		<dc:creator>Julie Lange</dc:creator>
		<pubDate>Sun, 16 Aug 2009 05:08:46 +0000</pubDate>
		<guid isPermaLink="false">http://www.proteinpower.com/drmike/?p=1853#comment-226656</guid>
		<description>Great post! 

This information came in very handy when I was researching the negative impact that statins have on glial progenitor cells in the brain.

Doctors like you are truly a blessing by providing straight forward and unbiased information to the public.

Thank you very much and keep up the good work!

- Julie

&lt;em&gt;Glad you enjoyed the post.&lt;/em&gt;</description>
		<content:encoded><![CDATA[<p>Great post! </p>
<p>This information came in very handy when I was researching the negative impact that statins have on glial progenitor cells in the brain.</p>
<p>Doctors like you are truly a blessing by providing straight forward and unbiased information to the public.</p>
<p>Thank you very much and keep up the good work!</p>
<p>- Julie</p>
<p><em>Glad you enjoyed the post.</em></p>
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		<title>By: "1st timer"</title>
		<link>http://www.proteinpower.com/drmike/cardiovascular-disease/1853/comment-page-2/#comment-211683</link>
		<dc:creator>"1st timer"</dc:creator>
		<pubDate>Sat, 25 Apr 2009 14:35:08 +0000</pubDate>
		<guid isPermaLink="false">http://www.proteinpower.com/drmike/?p=1853#comment-211683</guid>
		<description>Hi Dr. E,
My latest blood test showed elevated CRP, cholesterol and tri. Gloogling about CRP on the Internet I came across your blog. And I&#039;m so happy that I did! You clarified all I needed to know! But before I read your blog I have already purchased &quot;Country Life Ultra Concentrated Omega 3-6-9 &quot; with the following ingredients:

&quot;Vitamin E (as mixed tocopherols) 20 International Unit 67% 
Fish Oil Concentrate (from anchovy, mackerel, sardine) 800 Milligrams * 
Borage Seed Oil 800 Milligrams * 
Flax Oil (seed) 800 Milligrams * 
alpha -Linolenic Acid (from flax seed oil) 424 Milligrams * 
Linoleic Acid (from borage &amp; flax seed oil) 416 Milligrams * 
Oleic Acid (from borage &amp; flax seed oil) 362 Milligrams * 
Eicosapentaenoic Acid (EPA)(from fish oil concentrate - anchovy, mackerel, sardine) 240 Milligrams * 
Docosahexaenoic Acid (DHA)(from fish oil concentrate - anchovy, mackerel, sardine) 160 Milligrams * 
Gamma -Linoleic Acid (GLA)(from borage seed oil) 152 Milligrams&quot;

Having read your opinion about GLA, do you think I should avoid this formula all togother and stick to just omega 3 EFA and DHA? I&#039;ll also purchase NKO and curcumin as you suggested because I believe it will help me. I&#039;m sticking to a low carb lifestyle, avoiding cow dairy but I&#039;m occasionally eating  goat cheese. I need your input!!!
Thank you so very much for doing so much good to all of us with such great research, info.
and knowledge.
1st timer

&lt;em&gt;If you are truly following a low-carb lifestyle, I would avoid borage oil and other oils with a high content of GLA.  Lower insulin levels seems to allow these to convert to arachidonic acid more easily.  I have had many patients who were taking GLA (from whatever source) for back and/or joint pain.  When they switched to a low-carb diet, their pain got a little worse.  When I had them stop the GLA, the pain went away.  So, I always have people on low-carb diets avoid GLA.&lt;/em&gt;</description>
		<content:encoded><![CDATA[<p>Hi Dr. E,<br />
My latest blood test showed elevated CRP, cholesterol and tri. Gloogling about CRP on the Internet I came across your blog. And I&#8217;m so happy that I did! You clarified all I needed to know! But before I read your blog I have already purchased &#8220;Country Life Ultra Concentrated Omega 3-6-9 &#8221; with the following ingredients:</p>
<p>&#8220;Vitamin E (as mixed tocopherols) 20 International Unit 67%<br />
Fish Oil Concentrate (from anchovy, mackerel, sardine) 800 Milligrams *<br />
Borage Seed Oil 800 Milligrams *<br />
Flax Oil (seed) 800 Milligrams *<br />
alpha -Linolenic Acid (from flax seed oil) 424 Milligrams *<br />
Linoleic Acid (from borage &amp; flax seed oil) 416 Milligrams *<br />
Oleic Acid (from borage &amp; flax seed oil) 362 Milligrams *<br />
Eicosapentaenoic Acid (EPA)(from fish oil concentrate &#8211; anchovy, mackerel, sardine) 240 Milligrams *<br />
Docosahexaenoic Acid (DHA)(from fish oil concentrate &#8211; anchovy, mackerel, sardine) 160 Milligrams *<br />
Gamma -Linoleic Acid (GLA)(from borage seed oil) 152 Milligrams&#8221;</p>
<p>Having read your opinion about GLA, do you think I should avoid this formula all togother and stick to just omega 3 EFA and DHA? I&#8217;ll also purchase NKO and curcumin as you suggested because I believe it will help me. I&#8217;m sticking to a low carb lifestyle, avoiding cow dairy but I&#8217;m occasionally eating  goat cheese. I need your input!!!<br />
Thank you so very much for doing so much good to all of us with such great research, info.<br />
and knowledge.<br />
1st timer</p>
<p><em>If you are truly following a low-carb lifestyle, I would avoid borage oil and other oils with a high content of GLA.  Lower insulin levels seems to allow these to convert to arachidonic acid more easily.  I have had many patients who were taking GLA (from whatever source) for back and/or joint pain.  When they switched to a low-carb diet, their pain got a little worse.  When I had them stop the GLA, the pain went away.  So, I always have people on low-carb diets avoid GLA.</em></p>
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		<title>By: Michael</title>
		<link>http://www.proteinpower.com/drmike/cardiovascular-disease/1853/comment-page-2/#comment-209307</link>
		<dc:creator>Michael</dc:creator>
		<pubDate>Tue, 14 Apr 2009 06:47:43 +0000</pubDate>
		<guid isPermaLink="false">http://www.proteinpower.com/drmike/?p=1853#comment-209307</guid>
		<description>Great read Dr. Eades!
Looking back at the exclusion criteria:
1) Post-menopausal hormone-replacement therapy
2) Long-term oral glucocorticoids
3) History of alcohol or drug abuse
4) DM
5) Cancer within 5 years
6) Uncontrolled hypothyroidism

Why exactly were these specific patients excluded from the study?

&lt;em&gt;I don&#039;t know the precise reasons these criteria were excluded, but most studies have exclusion criteria to make both arms of the study as equal as possible while limiting confounding variables.&lt;/em&gt;</description>
		<content:encoded><![CDATA[<p>Great read Dr. Eades!<br />
Looking back at the exclusion criteria:<br />
1) Post-menopausal hormone-replacement therapy<br />
2) Long-term oral glucocorticoids<br />
3) History of alcohol or drug abuse<br />
4) DM<br />
5) Cancer within 5 years<br />
6) Uncontrolled hypothyroidism</p>
<p>Why exactly were these specific patients excluded from the study?</p>
<p><em>I don&#8217;t know the precise reasons these criteria were excluded, but most studies have exclusion criteria to make both arms of the study as equal as possible while limiting confounding variables.</em></p>
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		<title>By: Matt</title>
		<link>http://www.proteinpower.com/drmike/cardiovascular-disease/1853/comment-page-2/#comment-207879</link>
		<dc:creator>Matt</dc:creator>
		<pubDate>Sun, 29 Mar 2009 16:46:00 +0000</pubDate>
		<guid isPermaLink="false">http://www.proteinpower.com/drmike/?p=1853#comment-207879</guid>
		<description>The JUPITER data have been further tortured!   That&#039;s my recommendation for the title of your forthcoming blog post about the following new information that is now being presented about JUPITER.   You should come up with a list of ailments that statins prevent ... in the same vein as that list of ills of global warming.  By the way you&#039;ve got me looking a little more critically about the presumed consensus there ... and I&#039;m starting to reformulate my opinion.   Thanks for opening my eyes.

http://www.nytimes.com/2009/03/29/health/research/30heart.html?hp

&lt;em&gt;As long as there are big, big bucks in statins, the data will continue to be tortured.  I haven&#039;t read the paper on statins and clotting yet, but when I do, I&#039;ll let everyone know my opinion.  It may be that the drugs work for clot prevention, but at what expense?  And do they work better than the old tried and true methods?  Who knows?&lt;/em&gt;</description>
		<content:encoded><![CDATA[<p>The JUPITER data have been further tortured!   That&#8217;s my recommendation for the title of your forthcoming blog post about the following new information that is now being presented about JUPITER.   You should come up with a list of ailments that statins prevent &#8230; in the same vein as that list of ills of global warming.  By the way you&#8217;ve got me looking a little more critically about the presumed consensus there &#8230; and I&#8217;m starting to reformulate my opinion.   Thanks for opening my eyes.</p>
<p><a href="http://www.nytimes.com/2009/03/29/health/research/30heart.html?hp" rel="nofollow">http://www.nytimes.com/2009/03/29/health/research/30heart.html?hp</a></p>
<p><em>As long as there are big, big bucks in statins, the data will continue to be tortured.  I haven&#8217;t read the paper on statins and clotting yet, but when I do, I&#8217;ll let everyone know my opinion.  It may be that the drugs work for clot prevention, but at what expense?  And do they work better than the old tried and true methods?  Who knows?</em></p>
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		<title>By: Olga</title>
		<link>http://www.proteinpower.com/drmike/cardiovascular-disease/1853/comment-page-2/#comment-206173</link>
		<dc:creator>Olga</dc:creator>
		<pubDate>Mon, 09 Mar 2009 14:08:37 +0000</pubDate>
		<guid isPermaLink="false">http://www.proteinpower.com/drmike/?p=1853#comment-206173</guid>
		<description>Hi Dr. Eades:

Have you checked out Stephan&#039;s post on his blog &quot;whole health source?&quot;
It&#039;s a very interesting review of a recent Dutch study on the effects of Vitamin K2 on heart disease.  Here&#039;s the link:

http://wholehealthsource.blogspot.com/

&lt;em&gt;Interesting. Thanks for the link.&lt;/em&gt;</description>
		<content:encoded><![CDATA[<p>Hi Dr. Eades:</p>
<p>Have you checked out Stephan&#8217;s post on his blog &#8220;whole health source?&#8221;<br />
It&#8217;s a very interesting review of a recent Dutch study on the effects of Vitamin K2 on heart disease.  Here&#8217;s the link:</p>
<p><a href="http://wholehealthsource.blogspot.com/" rel="nofollow">http://wholehealthsource.blogspot.com/</a></p>
<p><em>Interesting. Thanks for the link.</em></p>
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		<title>By: nonegiven</title>
		<link>http://www.proteinpower.com/drmike/cardiovascular-disease/1853/comment-page-2/#comment-203117</link>
		<dc:creator>nonegiven</dc:creator>
		<pubDate>Thu, 05 Feb 2009 04:13:08 +0000</pubDate>
		<guid isPermaLink="false">http://www.proteinpower.com/drmike/?p=1853#comment-203117</guid>
		<description>&lt;i&gt;Ah, maybe so. I don’t even know how that got set up. Maybe one of my former tech gurus set it up, because I certainly didn’t. Not that there is a problem with it, I just don’t even know how it works. Do you get it that way? &lt;/i&gt;

I&#039;m subscribed to both posts and comments with Bloglines.  Most blogs don&#039;t have a way to subscribe to comments without subscribing to each post&#039;s comments individually.  I sure hope you keep it.

&lt;em&gt;I&#039;ll keep it.  I don&#039;t have a clue as to how to get rid of it even if I wanted to.&lt;/em&gt;</description>
		<content:encoded><![CDATA[<p><i>Ah, maybe so. I don’t even know how that got set up. Maybe one of my former tech gurus set it up, because I certainly didn’t. Not that there is a problem with it, I just don’t even know how it works. Do you get it that way? </i></p>
<p>I&#8217;m subscribed to both posts and comments with Bloglines.  Most blogs don&#8217;t have a way to subscribe to comments without subscribing to each post&#8217;s comments individually.  I sure hope you keep it.</p>
<p><em>I&#8217;ll keep it.  I don&#8217;t have a clue as to how to get rid of it even if I wanted to.</em></p>
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		<title>By: nonegiven</title>
		<link>http://www.proteinpower.com/drmike/cardiovascular-disease/1853/comment-page-2/#comment-203093</link>
		<dc:creator>nonegiven</dc:creator>
		<pubDate>Wed, 04 Feb 2009 20:48:15 +0000</pubDate>
		<guid isPermaLink="false">http://www.proteinpower.com/drmike/?p=1853#comment-203093</guid>
		<description>&lt;i&gt;I am clueless as to what’s going on here. I don’t have a weekly newsletter, so I don’t know what you’re actually getting.&lt;/i&gt;

Possibly he is calling this a newsletter, it seems to be the blog posts delivered by email instead of a blog reader:

Subscribe via Email
Get Dr. Mike&#039;s Posts Delivered to Your Inbox

&lt;em&gt;Ah, maybe so.  I don&#039;t even know how that got set up.  Maybe one of my former tech gurus set it up, because I certainly didn&#039;t.  Not that there is a problem with it, I just don&#039;t even know how it works.  Do you get it that way?  If so, were the apostrophes screwed up? Maybe I had better subscribe myself so I can see what comes.&lt;/em&gt;</description>
		<content:encoded><![CDATA[<p><i>I am clueless as to what’s going on here. I don’t have a weekly newsletter, so I don’t know what you’re actually getting.</i></p>
<p>Possibly he is calling this a newsletter, it seems to be the blog posts delivered by email instead of a blog reader:</p>
<p>Subscribe via Email<br />
Get Dr. Mike&#8217;s Posts Delivered to Your Inbox</p>
<p><em>Ah, maybe so.  I don&#8217;t even know how that got set up.  Maybe one of my former tech gurus set it up, because I certainly didn&#8217;t.  Not that there is a problem with it, I just don&#8217;t even know how it works.  Do you get it that way?  If so, were the apostrophes screwed up? Maybe I had better subscribe myself so I can see what comes.</em></p>
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		<title>By: Roger Wilgus</title>
		<link>http://www.proteinpower.com/drmike/cardiovascular-disease/1853/comment-page-2/#comment-203061</link>
		<dc:creator>Roger Wilgus</dc:creator>
		<pubDate>Tue, 03 Feb 2009 19:05:23 +0000</pubDate>
		<guid isPermaLink="false">http://www.proteinpower.com/drmike/?p=1853#comment-203061</guid>
		<description>Dr. Mike,

I recently subscribed to your weekly newsletter and am still exploring the wealth of information on your various sites.  

However, there are two very annoying aspects to the weekly publication.  First, I get a script error message every time I attempt to access your emailing.  Every time I return, the message also returns, and must be disposed of.  Please try to have this fixed.

Secondly, today&#039;s communique about Fat Head had the very irritating defect of having a double-space in the place of every apostrophe.  This interrupts the reading flow, and makes it very difficult to appreciate the content.  Surely this can be fixed easily.

Aside from those two problems, I&#039;m loving it.  I bought &quot;The Slow Burn...&quot; a couple of years ago, and it&#039;s fantastic.  Now I&#039;m also a low-carb eater, and a disciple of Dr. Malcolm Kendrick&#039;s opinions regarding cholesterol and heart disease.  What a bill of goods the public has been sold by the Judas-like physicians and others who make up the NIH, the NCEP board and the FDA.  As far as I&#039;m concerned the facts are irrefutable:  Cholesterol does not cause heart disease, and low cholesterol can be dangerous or fatal.  But Big Pharma has so enslaved the medical establishment that it will be a long, long time before your personal physician is likely to accept this truth.

&lt;em&gt;I am clueless as to what&#039;s going on here.  I don&#039;t have a weekly newsletter, so I don&#039;t know what you&#039;re actually getting.  Second, I&#039;ve looked at the Fat Head post on a couple of other computers, and it looked fine on all.  Maybe some other readers can chime in on this one because I don&#039;t know what to tell you.&lt;/em&gt;</description>
		<content:encoded><![CDATA[<p>Dr. Mike,</p>
<p>I recently subscribed to your weekly newsletter and am still exploring the wealth of information on your various sites.  </p>
<p>However, there are two very annoying aspects to the weekly publication.  First, I get a script error message every time I attempt to access your emailing.  Every time I return, the message also returns, and must be disposed of.  Please try to have this fixed.</p>
<p>Secondly, today&#8217;s communique about Fat Head had the very irritating defect of having a double-space in the place of every apostrophe.  This interrupts the reading flow, and makes it very difficult to appreciate the content.  Surely this can be fixed easily.</p>
<p>Aside from those two problems, I&#8217;m loving it.  I bought &#8220;The Slow Burn&#8230;&#8221; a couple of years ago, and it&#8217;s fantastic.  Now I&#8217;m also a low-carb eater, and a disciple of Dr. Malcolm Kendrick&#8217;s opinions regarding cholesterol and heart disease.  What a bill of goods the public has been sold by the Judas-like physicians and others who make up the NIH, the NCEP board and the FDA.  As far as I&#8217;m concerned the facts are irrefutable:  Cholesterol does not cause heart disease, and low cholesterol can be dangerous or fatal.  But Big Pharma has so enslaved the medical establishment that it will be a long, long time before your personal physician is likely to accept this truth.</p>
<p><em>I am clueless as to what&#8217;s going on here.  I don&#8217;t have a weekly newsletter, so I don&#8217;t know what you&#8217;re actually getting.  Second, I&#8217;ve looked at the Fat Head post on a couple of other computers, and it looked fine on all.  Maybe some other readers can chime in on this one because I don&#8217;t know what to tell you.</em></p>
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		<title>By: dan</title>
		<link>http://www.proteinpower.com/drmike/cardiovascular-disease/1853/comment-page-2/#comment-201725</link>
		<dc:creator>dan</dc:creator>
		<pubDate>Sun, 11 Jan 2009 05:13:10 +0000</pubDate>
		<guid isPermaLink="false">http://www.proteinpower.com/drmike/?p=1853#comment-201725</guid>
		<description>To think that those involved in the &quot;nutraceuticals&quot; industry. Rescue 1250, etc do not have a vested interest in &quot;hooking America on drugs&quot; is naive.
IF the companies are soooo interested in helping people to stay healthy then why not spend the money required by the pharmaceutical industry to test if bilberry or saw palmetto really does anything that they claim it does?  Oh wait, then they might not show benefit and people won&#039;t skip a heating or electric bill to get their &quot;supplements&quot; if they show it does NOT work.
Snake oil is snake oil, no matter who sells it.

&lt;em&gt;I agree 100 percent.  But there is no patent protection for individual nutraceuticals, so there simply isn&#039;t the money to test them extensively.  And as far as snake oil goes, if I&#039;m going to take snake oil, I would rather take snake oil that costs me $15 per month than snake oil that costs me $150 per month and carries with it a host of side effects, some of which can be fatal.  As far as I know, no one has ever died from bilberry or saw palmetto.&lt;/em&gt;</description>
		<content:encoded><![CDATA[<p>To think that those involved in the &#8220;nutraceuticals&#8221; industry. Rescue 1250, etc do not have a vested interest in &#8220;hooking America on drugs&#8221; is naive.<br />
IF the companies are soooo interested in helping people to stay healthy then why not spend the money required by the pharmaceutical industry to test if bilberry or saw palmetto really does anything that they claim it does?  Oh wait, then they might not show benefit and people won&#8217;t skip a heating or electric bill to get their &#8220;supplements&#8221; if they show it does NOT work.<br />
Snake oil is snake oil, no matter who sells it.</p>
<p><em>I agree 100 percent.  But there is no patent protection for individual nutraceuticals, so there simply isn&#8217;t the money to test them extensively.  And as far as snake oil goes, if I&#8217;m going to take snake oil, I would rather take snake oil that costs me $15 per month than snake oil that costs me $150 per month and carries with it a host of side effects, some of which can be fatal.  As far as I know, no one has ever died from bilberry or saw palmetto.</em></p>
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		<title>By: dan</title>
		<link>http://www.proteinpower.com/drmike/cardiovascular-disease/1853/comment-page-2/#comment-201724</link>
		<dc:creator>dan</dc:creator>
		<pubDate>Sun, 11 Jan 2009 05:09:15 +0000</pubDate>
		<guid isPermaLink="false">http://www.proteinpower.com/drmike/?p=1853#comment-201724</guid>
		<description>The study was stopped because of an overwhelming benefit (i.e. not ethical to continue).  Anyone who is involved in basic or clinical research knows about a DSMB (Data Safety and Monitoring Board)  For those skeptics, this board is INDEPENDENT of those involved in the trial.  They are required to ask to stop the trial for harm OR benefit.
I agree that the absolute risk is not impressive, but to completely dismiss this study is as ridiculous as the hype it has received.  
Argue the merits:  40% had metabolic syndrome (not low risk).
Of course you exclude those on HRT, hypothyroid, liver dysfunction and kidney dysfunction.  You are eliminating confounding factors (things that make it difficult to figure out why someone died or had an adverse event.)
In the studies looking at folic acid in pregnancy referenced in previous post, would you include or exclude mom&#039;s who took crack cocaine?  Exclude them!  They are not the population you are looking at.
Mike, while I respect your right to an opinion, if you are going to claim to be scientific than please also be academically honest and don&#039;t mislead those who do not know better. 
Paul Ridker actually expected the DSMB to call him telling him that the side effects were too high; not that there was a margin of benefit outside of those set BEFORE the trial is conducted.
Cholesterol is not the only answer.  Inflammation clearly plays a role.  But, without the cholesterol forming foam cells and yellow gook in the arteries, heart attacks and strokes don&#039;t happen.

Daniel

&lt;em&gt;I wouldn&#039;t say the benefit was overwhelming enough to justify stopping the study.  I suspect a little confirmation bias was in play.

You&#039;ve misrepresented my point on the study exclusion factors.  I&#039;m making the point that the criteria for inclusion was so narrow that the findings of the study apply to an extremely small group of people, yet the message is that statins work (not just this specific statin, but all statins) are beneficial to people even with normal LDL levels.

I&#039;m not trying to mislead people, but to present these studies as I see them.  And I don&#039;t think I indulged in academic dishonesty.&lt;/em&gt;</description>
		<content:encoded><![CDATA[<p>The study was stopped because of an overwhelming benefit (i.e. not ethical to continue).  Anyone who is involved in basic or clinical research knows about a DSMB (Data Safety and Monitoring Board)  For those skeptics, this board is INDEPENDENT of those involved in the trial.  They are required to ask to stop the trial for harm OR benefit.<br />
I agree that the absolute risk is not impressive, but to completely dismiss this study is as ridiculous as the hype it has received.<br />
Argue the merits:  40% had metabolic syndrome (not low risk).<br />
Of course you exclude those on HRT, hypothyroid, liver dysfunction and kidney dysfunction.  You are eliminating confounding factors (things that make it difficult to figure out why someone died or had an adverse event.)<br />
In the studies looking at folic acid in pregnancy referenced in previous post, would you include or exclude mom&#8217;s who took crack cocaine?  Exclude them!  They are not the population you are looking at.<br />
Mike, while I respect your right to an opinion, if you are going to claim to be scientific than please also be academically honest and don&#8217;t mislead those who do not know better.<br />
Paul Ridker actually expected the DSMB to call him telling him that the side effects were too high; not that there was a margin of benefit outside of those set BEFORE the trial is conducted.<br />
Cholesterol is not the only answer.  Inflammation clearly plays a role.  But, without the cholesterol forming foam cells and yellow gook in the arteries, heart attacks and strokes don&#8217;t happen.</p>
<p>Daniel</p>
<p><em>I wouldn&#8217;t say the benefit was overwhelming enough to justify stopping the study.  I suspect a little confirmation bias was in play.</p>
<p>You&#8217;ve misrepresented my point on the study exclusion factors.  I&#8217;m making the point that the criteria for inclusion was so narrow that the findings of the study apply to an extremely small group of people, yet the message is that statins work (not just this specific statin, but all statins) are beneficial to people even with normal LDL levels.</p>
<p>I&#8217;m not trying to mislead people, but to present these studies as I see them.  And I don&#8217;t think I indulged in academic dishonesty.</em></p>
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